Competence Center of Oral Biology

Our laboratory uses fundamental cellular biological methods, preclinical methods and clinical trials for the development of causal therapeutic strategies in regenerative dentistry. We focus on the healing of dental implants and biomaterials with a special emphasis on dental implantology and periodontology. We deal with the elucidation of molecular and cellular mechanisms of oral wound healing in healthy and ill patients. It is our aim to study the clinical relevance of natural and synthetic molecules, as well as biological fluids in dentistry.

Applied Methods

Our methods include fundamental in vitro cell culture techniques with a focus on oral and bone cells such as periodontal fibroblasts, osteoblasts and osteoclasts. Based on a broad range of methods for the determination of proliferation, migration, differentiation, signalling and gene expression, we test the reaction of cells to various biomaterials, bone transplants, saliva and bioactive molecules of natural origin. Our portfolio includes various preclinical models with a focus on bone regeneration. In addition, we examine the skull anatomy of various mice models with the aid of CT and geometric morphometry.